Each decision-making tool should be tested and validated in real case studies to be practical and fit to global problems. The application of multi-criteria decision-making methods (MCDM) is currently a trend to rank alternatives. In the literature, there are several multi-criteria decision-making methods according to their classification. During our experimentation on the Combined Compromise Solution (CoCoSo) method, we encountered its limits for real cases. The authors examined the applicability of the CoCoFISo method (improved version of combined compromise solution), by a real case study in a university campus and compared the obtained results to other MCDMs such as Preference Ranking Organisation Method for Enrichment Evaluations (PROMETHEE), Weighted Sum Method (WSM) and Technique for Order Preference by Similarity to the Ideal Solution (TOPSIS). Our research finding indicates that CoCoSo is an applied method that has been developed to solve complex multi variable assessment problems, while CoCoFISo can improve the shortages observed in CoCoSo and deliver stable outcomes compared to other developed tools. The findings imply that application of CoCoFISo is suggested to decision makers, experts and researchers while they are facing practical challenges and sensitive questions regarding the utilization of a reliable decision-making method. Unlike many prior studies, the current version of CoCoSo is unique, original and is presented for the first time. Its performance was approved using several strategies and examinations.

In recent era prediction of enzyme class from an unknown protein is one of the challenging tasks in bioinformatics. Day to day the number of proteins is increases as result the prediction of enzyme class gives a new opportunity to bioinformatics scholars. The prime objective of this article is to implement the machine learning classification technique for feature selection and predictions also find out an appropriate classification technique for function prediction. In this article the seven different classification technique like CRT, QUEST, CHAID, C5.0, ANN (Artificial Neural Network), SVM and Bayesian has been implemented on 4368 protein data that has been extracted from UniprotKB databank and categories into six different class. The proteins data is high dimensional sequence data and contain a maximum of 48 features.To manipulate the high dimensional sequential protein data with different classification technique, the SPSS has been used as an experimental tool. Different classification techniques give different results for every model and shows that the data are imbalanced for class C4, C5 and C6. The imbalanced data affect the performance of model. In these three classes the precision and recall value is very less or negligible. The experimental results highlight that the C5.0 classification technique accuracy is more suited for protein feature classification and predictions. The C5.0 classification technique gives 95.56% accuracy and also gives high precision and recall value. Finally, we conclude that the features that is selected can be used for function prediction.